Should You Use L-Glutamine for Leaky Gut?

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Can l-glutamine help with leaky gut
Wellness Mama » Blog » Health » Should You Use L-Glutamine for Leaky Gut?

If your doctor has told you that you have a leaky gut, you’re likely considering a gut supporting diet. But supplements may also be helpful for leaky gut. One of my favorite gut support supplements is l-glutamine. In this post, I’ll cover all the amazing benefits of l-glutamine for the gut and how you can use it.

What Is Leaky Gut?

As food enters the intestines, it is broken down into individual nutrients that can pass through the tight junctions of the intestinal lining and into the bloodstream to be used in the rest of the body. The gut lining keeps large particles, bacteria, and toxins from passing through in the same way that nutrients do. These undesirable particles are swept out of the body with other waste.

However, with leaky gut (also known as intestinal hyperpermeability), the intestinal lining is not as robust and allows these particles and toxins through the intestinal wall and into the bloodstream. This can wreak havoc on the body.

A 2017 article in Frontiers in Immunology describes leaky gut syndrome as “a dangerous warning signal for autoimmune disease.” According to microbiologist Kiran Krishnan, about 80% of the body’s immune system and tissue resides in the digestive tract, which is why leaky gut syndrome and autoimmune diseases are often tied together.

Causes of Leaky Gut

Steve Wright, the creator of, sat down for a podcast episode with me to talk about leaky gut, heartburn, and digestion. During the podcast, he describes how his program helps individuals identify 19 specific triggers that may cause leaky gut.

These are the main factors that are believed to play a role in the development of leaky gut:

  • Poor diet
  • Stress
  • Environmental toxins
  • Bacterial imbalances
  • Genes

It’s difficult to pinpoint the exact reasons leaky gut occurs and it’s likely a combination of these factors. Some triggers are out of our hands (genetics), but many are without our realm of control.

Symptoms of Leaky Gut

Leaky gut leads to more than just stomach pain. Symptoms of leaky gut are often quite different from person to person. Some people can even have leaky gut syndrome without experiencing symptoms. Other times it can be painful like Crohn’s disease. This is why it’s so difficult to diagnose (and possibly why mainstream medicine is having a hard time believing that leaky gut is real!).

These symptoms may indicate that an individual’s intestinal lining isn’t working correctly:

Leaky gut often occurs alongside other chronic illnesses plaguing many people throughout the western world, including autoimmune diseases, cancer, respiratory infections, Parkinson’s disease, and more.

What Is L-Glutamine?

L-glutamine plays a vital role in a variety of processes. It especially helps in the case of leaky gut because it supports the body in restoring the intestinal lining.

This essential amino acid provides the body with support by:

  • removing waste (such as ammonia)
  • building proteins
  • stabilizing blood glucose levels
  • building nucleic acids for DNA

This supplement (in its powdered form) became a popular supplement for bodybuilders because it supports healthy muscles. A study from 2015 states that this nutrient helps athletes recover and experience less muscle soreness following strenuous physical activity.

Benefits of L-Glutamine on the Body

Besides helping with muscle recovery, l-glutamine has many other benefits. Even if leaky gut wasn’t something on my radar, I would use it for some of these other benefits.

Supports Healthy Brain Function

A healthy brain (just like the rest of the body) requires a variety of vitamins and nutrients to maintain a healthy mental state. Glutamine is one of those valuable amino acids for brain health.

Glutamine makes up a large portion of the central nervous system. A lack of glutamine in the body can interrupt natural brain cycles and lead to epilepsy, anxiety, depression, bipolar disorders, and other mood or nervous system disorders.

Supports a Healthy Digestive System and Bowel Movements

It is only natural that a condition known as “leaky gut” would cause problems in the digestive system and bowels.

Gut-related issues seem to be more common than we think. Dr. Ken Brown revealed in this podcast with me that today about 20% of the population experience IBS. One of the biggest concerns for digestive issues and bowel issues is inflammation.

Fortunately, l-glutamine can support the body in lowering the inflammatory response in IBS and other chronic illnesses, according to a 2017 review. The review found that stressors (including illness) deplete glutamine, so supplementing can help.

Additionally, this review explains that glutamine supports cellular health which is also important for gut health.

Supports Weight Loss

This nutrient has been used to promote weight loss and fat burning by many in the fitness industry. In one study, after just six weeks of receiving the supplements, patients with type 2 diabetes saw a dramatic reduction in some of their cardiovascular risk factors as well as body composition. Researchers believe that l-glutamine helps to reduce insulin levels and stabilizes blood glucose, supporting the body in burning more fat and building muscle.

Can L-Glutamine Support the Gut?

As mentioned above, l-glutamine supports healthy digestion and overall gut health. A French study describes glutamine as a vital nutrient for overall intestinal health (including leaky gut syndrome).

Supports Healthy Food Choices

Due to its ability to support healthy blood glucose levels, l-glutamine supports healthy eating habits, instead of feeding cravings for sugars and carbohydrates that cause inflammation throughout the body (making leaky gut worse). Additionally, a 2019 study shows that low glutamine levels in the brain were associated with heavy alcohol consumption and cravings, too.

Supports Intestinal Health

Stomach ulcers and ulcerative colitis often accompany leaky gut as these conditions directly affect the intestines.

L-glutamine has shown promising benefits in supporting the health of the intestines. A European review looked at the role glutamine played on intestinal health and determined that the amino acid has a “protective effect on intestinal tissues.”

What Are the Side Effects of L-Glutamine?

This supplement is considered generally safe for most people. If you have a medical condition or are unsure at all, always check with your doctor to discuss whether this supplement is safe for you. If you are pregnant or breastfeeding, don’t use this supplement without talking with your doctor as it’s unclear whether it’s safe. Your doctor may recommend getting your share of this nutrient in food form instead of supplements.

Side effects are rare, though some people have an allergic reaction to this supplement. If you notice signs of an allergic reaction like swelling, hives, nausea, etc., get medical attention immediately.

How to Add L-Glutamine to Your Diet

L-glutamine is found naturally in a variety of protein sources. Include these foods in your diet to naturally reap the benefits of this nutrient:

  • Grass-fed beef
  • Bone broth
  • Free-range chicken
  • Spinach
  • Beets
  • Peas
  • Broccoli rabe
  • Wild-caught cod and salmon
  • Turkey
  • Cabbage
  • Cottage cheese
  • Asparagus
  • Venison

Eating a whole foods diet with at least three servings of these foods daily is a great place to start when increasing l-glutamine. Probiotics are also helpful for supporting healthy digestion so adding any of the above vegetables in fermented form is a great idea. Beet kvass is one tasty idea.

Taking l-glutamine as a supplement to complement a healthy diet can support your journey to a healthier gut, too. For some, acquiring enough l-glutamine through food may be easy. But, to get a consistent amount daily, supplementing may be a better route to take.

When I was diagnosed with Hashimoto’s Thyroiditis, I knew I needed to be taking care of my gut health. I started this gut-healthy diet and made sure I was getting ample amounts of l-glutamine. This protocol made a huge difference in supporting my body’s natural health.

I like these l-glutamine capsules, but you can also find l-glutamine powder.

The Power of the Body

What I find really interesting about using these kinds of supplements to support health is that they are things easily found in food. That means that you don’t necessarily need to spend a lot of money. Instead, you can be more intentional about the food you eat and get many of the benefits of this supplement.

If you are experiencing any of the symptoms of leaky gut syndrome, l-glutamine is an essential nutrient to consider adding to your diet with your doctor’s approval.

This article was medically reviewed by Dr. Scott Soerries, MD, Family Physician and Medical Director of SteadyMD. As always, this is not personal medical advice and we recommend that you talk with your doctor.

Katie Wells Avatar

About Katie Wells

Katie Wells, CTNC, MCHC, Founder of Wellness Mama and Co-founder of Wellnesse, has a background in research, journalism, and nutrition. As a mom of six, she turned to research and took health into her own hands to find answers to her health problems. is the culmination of her thousands of hours of research and all posts are medically reviewed and verified by the Wellness Mama research team. Katie is also the author of the bestselling books The Wellness Mama Cookbook and The Wellness Mama 5-Step Lifestyle Detox.


103 responses to “Should You Use L-Glutamine for Leaky Gut?”

  1. Ruth E. Chidley Avatar
    Ruth E. Chidley

    Hi Katie,
    I would like to attend the Webinar but every time I click the link, I get a warning that states the link is an unsecured site, with my personal information exposed…not sure what is happening.
    I am new to your blog and am so thankful I found you. I have 4 autoimmune diseases, one of which is Hashimoto’s. I was diagnosed with Hashimoto’s 30 years ago with an antibody count of over 10,000. My doctor, at the time, said my counts were the highest he had seen in his 30+ years of practice. Unfortunately, he also said there was nothing I could do to help change it. When I found your blog, I wanted to cry. For the first time in my life, I heard there are things I can do to help bring healing for my Hashimoto’s and leaky gut. I’ve eaten an unprocessed food diet for many years hoping it would help me. I’m sure it has but I now know there is more I can do.
    Thank you, Katie, for all your hard work and research.
    May you and your family have a blessed weekend.

  2. Q Avatar

    When I was first beginning my quest to find things that would help my Graves’ Disease, L-Glutamine was one of the things that kept coming up in my research. I was taking it with other supplements at the time (haven’t taken it for a while, as I’m feeling MUCH better) but I feel that it made a great difference for me. I was taking about 30g a day, in 2 – 15g doses, morning and evening. I’m going to see if I can include it in some gelatine gummies, just to make it easier to take regularly – it’s kinda grainy stuff to drink in almost anything! Has anyone tried this? Please comment if so.

  3. Laura Avatar

    I have read to take it before meals on an empty stomach. I was taking 1 gram in the morning (capsule) until I read about the range of safe dosages being 4-10 grams. Thinking I was starting out slow, I took 4 grams the other morning and within two hours was doubled over with vomiting and diarrhea. Be careful!!

  4. cyndi vela Avatar
    cyndi vela

    As I read your article, I immediately thought of GMO foods. If I understand GMO correctly, eating GMO foods will cause the intestinal walls to become thinner and thinner. It’s how a bug is killed from GMO crops; it explodes their gut. Is this correct?

    1. Angela Avatar

      Wow! I never knew that about GMO. I will definitely research this now. Now on to the topic at hand. .
      My 12 year old daughter has extreme ache on her forehead and I’m wondering if it could be caused from her gut?

      1. Kristin Avatar

        Try cod liver oil capsules with Vitamin K and butter oil Green. Pasture is a good brand.

  5. Alicia Fettig Avatar
    Alicia Fettig

    I’m also curious about the with or without food question. My ND told me to take it with food. Also, is it tolerated by most? I have some and used it for a while but question whether I was tolerating it or not. If not, any suggestions for other ways to get it from food sources? Thanks!

    1. Elysia Avatar

      Bone broth is highly recommended for leaky gut – I recently started making it myself. I can’t remember but I think it may contain l-glutamine? A quick Google would probably answer that.

  6. Ashley Avatar

    My doctor advised me to take L-Glutamine for 2-3 months only… have you heard anything about this being only a temporary supplement. If you aren’t fully healed in 3 months would you keep taking it?

  7. Julie Avatar

    I’ve been researching L-Glutamine, and I’m seeing some confusion about its safety for nursing mamas? Anyone have thoughts on this? Katie do you take it while nursing?
    Thanks 😀

      1. Wendy Avatar

        Hi Katie,
        How much L-glutamine did you take while nursing? Were there other supplements you took while nursing that helped heal your leaky gut or put your AI in remission?

        1. Wellness Mama Avatar

          I only needed 500-1000 mg a day to drastically help my hashimotos, but I’d definitely check with a naturopathic doc if you are nursing also..

          1. julie Avatar

            Is 500 to 1000mg the same as 5 – 10 gram? I to have hashimotos.

  8. Georgia Defreeze Avatar
    Georgia Defreeze

    Thank you for another great article. I am also confused with all the conflicting information on glutamine, glutamate, and glutathione! Dr. Mercola isn’t the only one who has written articles on the excitotoxins. Do all forms have the possibility of causing excitotoxins and/or negative effects?

    1. Elysia Avatar

      I’m not sure I would trust that article. It is 10 years old and very confusing with large pieces of missing information. He states that this excitotoxin issue occurs with high/mega doses and ONLY if it is inside the brain cell, otherwise it is harmless. But he never defines “high dose” – for all we know, high dose could be 100 grams! And he does not say what would make it go inside the brain or stay outside. He also does not cite a single source, other than this one doctor. The purpose of the article seems to be to back up Dr. Mercola’s original opinion on the issue, not to give a neutral, objective look at it. I think this would be a great question to bring up in the Q&A during the webinar! Maybe they can shed some light on these concerns.

      1. Charisse Avatar

        I have bad reactions to many drugs so this will likely not be your experience. However, l-glutamine isn’t the right answer for everyone. I was diagnosed with leaky gut, have been gluten free for over 6 years (very strict gf) and I was unable to tolerate even 2 grams of Source Naturals L-Glutamine powder. I think those of us who can’t tolerate it are extremely rare, judging by the success of everyone I see using it online in supplement reviews, etc. But wow, I have tried it several times since I bought a big canister of it, and nope. It is not for me! It makes me feel terrible and I wake up with my face very puffy. It apparently affects the kidneys and liver and brain if your body is unable to utilize it for some reason,

        1. Loren Avatar

          I too could not tolerate l-glutamine. I began using it because I was hoping to heal my leaky gut. I took 1/4 tsp in the morning and a 1/4 teaspoon in the afternoon mixed with juice. Within 3 weeks I was angry and depressed. It also caused dermatitis on my face, which NO ONE anywhere says anything about it causing rashes. I know for a fact that the l-glutamine was causing it. As soon as I stopped taking it I was better within two days and my rash is almost gone. I also was developing frozen shoulder, which miraculously left when I stopped the l-glutamine. Everyone should approach the use of this supplement with extreme caution.

  9. Kori Avatar

    Hi Katie–

    I’m exclusively nursing a 3 month old and I’m a type 1 diabetic that has recently been diagnosed with Celiac Disease. I’m wondering if L-glutamine is something that is OK while breastfeeding. I’m having a really hard time finding good information about it’s impact–positive or otherwise!

    Thanks very much for your insight!

  10. Shelly Avatar

    Hi Katie! Thanks as always for the great tips.
    is it safe to take while pregnant?

  11. Anita Avatar

    I won’t be able to attend this webinar but really want the information! Is it all available in the surviving to thriving ebook? I was diagnosed with leaky gut/high intestinal permiability 6 years ago and it is just getting worse. Severe sinus infections, hormonal imbalance, insomnia, adrenal fatigue and iron deficient anemia are just some of the manifestations of this problem. I eat a nourishing traditions gluten free diet but this is not helping me.

    1. Elysia Avatar

      It says the webinar recording will be available the day after it airs live. If you click through and sign up, they should send you a link once it’s available. I can’t attend live either 🙂

    2. Michelle Avatar

      Have you considered food sensitivity? I had a Cyrex test completed and learned that I was eating a lot of foods (healthy foods) that I had sensitivity to. I could eat them and feel fine, but it was causing body aches. Once I removed them, I haven’t had anymore body aches.

    3. Sumi Avatar

      Hi anitha,

      I am Sumi here. Did you really test for leakygut or its just through clinical symptoms.

    4. Sumi Avatar

      Hi Anitha,

      I am sumi from India. What kind of diet do you follow for leaky gut ???
      Please share.


  12. Vicki Avatar

    I’ve been putting l-glutamine powder into my coconut oil coffee. Would that be okay?

  13. Diana Avatar

    Glad to know you are up-to-date on this supplement. My doctor has had me on this for some time now and it has helped tremendously. Also it was good to better know the science behind it.

  14. Terri Avatar

    Is the dosage amount 10-40 GRAMS or MILIGRAMS? Where do you purchase yours?
    Thanks in advance!

    1. Elysia Avatar

      Grams. Though I’d start with 5, which is generally 1 scoop. I’ve been taking 1 scoop/5g for several weeks and just increased to 2 scoops/10g. 10-40g is quite a wide range – I want to do a little more research to see if there are other dose recommendations, and what they say in the webinar. For now I’ll stick with 10g. I use Swanson Vitamins Pharmceutical Grade AjiPure L-Glutamine Powder.
      Hope that helps 🙂 🙂

  15. Mary Avatar

    I have two year old daughter that is struggling with skin problems. Is this something she can supplement wit? If so how much and with what?

    1. Leizel Avatar

      Most skin problems are directly connected to Leaky Gut. Supplementing with L-Glutamine rebuilds the intestinal wall to stop LG.

    2. Ashley Avatar

      Please do NOT give children any supplements without talking to their doctor first!

      They process things differently and have different needs than an adult.

  16. Chantal Avatar

    I am confused…was told by N.D. for gut and sugar craving to take L-Glutamine on empty stomach…it says here to take it with food .
    Should I take it with or without food. Merci!

    1. Elysia Avatar

      Hmm… Maybe we’ll find out in webinar? If they don’t discuss it, maybe someone can ask during the Q&A and then post the answer here for the rest of us who can’t attend live. Thanks!

    2. Michael Avatar

      Hi Elysia,

      I’ve always taken it without food. I can actually feel its effects. Since it doesn’t need anything added to be effective, I would suggest you take it without. However, I’m also an experimenter by nature. Try both & see if you can feel a difference. It won’t be harmful. 🙂

  17. Lily Avatar

    Thank you for posting this! The more info out there about leaky gut, the better. I wish doctors would consider it more. -Lily

  18. chris czajkowski Avatar
    chris czajkowski

    I found this when looking for glutamine in foods:
    “Glutamine is found in many high protein foods such as dairy products, fish, beef and beans. Taking a protein supplement rich in glutamine in addition to carbohydrate, post exercise, may be sufficient to maintain glutamine status(4).”
    My practice is: Try food first before supplements.
    Love your blog.

    1. leeann arnold Avatar
      leeann arnold

      yes, I think you should try food first too. I tried Glutamine on an empty stomach. That is the way you are supposed to take it and you are also supposed to work yourself up slowly on it. But it make me sick to my stomach. I got the tablets, but they say the powder is better and you mix in water? Maybe everyone is different.
      But I felt very nauseated.

      1. tif Avatar

        there are two kinds of glutamine and the one kind you can’t take on an empty stomach its called free form. You should take with food unless you buy the Trans-Alanyl which can be on an empty stomach. Also, you have to wean onto it in small dose to start like 2.5 grams twice a day.

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