My Review of OneSkin Skincare Products

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Wellness Mama » Blog » Reviews » My Review of OneSkin Skincare Products

Skincare suddenly becomes more important to women once we’ve reached our thirties and forties. The products that seemed like a luxury before now seem essential for looking and feeling our best. OneSkin is a skincare company that develops products to promote skin health at the molecular level.

I love their products, which support healthy skin from the outside while I focus on my diet for the inside. While it’s a topical product, I’m fascinated by how they focus on rejuvenation from within the cell. 

Here are my thoughts on OneSkin products and how they’re revolutionizing the way we look at skincare and promoting skin longevity.

What Causes Skin to Age?

Skin health is very much connected to our overall health. In fact, the skin often reflects what’s going on inside the gut and the blood vessels. Aging in general is caused by a loss of integrity within the cells of the body – wherever they may be, including our skin cells. 

How fast our skin ages depends on our genetics and our environment. Things like too much sun, pollution, diet, and lifestyle choices can make aging worse. These skin stressors damage the skin and create senescent “zombie” cells, now known to be the root cause of skin aging.

When cells become senescent, they stop dividing like normal cells. They grow larger and just sit there like zombies, accumulating over time. However, they still influence metabolism, and not in a good way. While taking up space, they begin secreting pro-aging factors, including inflammatory cytokines, and immune modulators.

Senescent cells also influence the healthy cells surrounding them. They trigger neighboring cells to begin aging faster and start breaking down collagen. This leads to widespread inflammation, poor barrier function, and visible signs of aging. That’s when we look in the mirror and start noticing sagging, fine lines, and wrinkles.

Our skin is also the main protective barrier against the external environment. It filters out toxins, controls hydration, protects us against UV radiation, and more. Maintaining healthy, strong skin throughout our lives protects the health of our internal organs.

What Can We Do to Reduce Internal Aging?

Inflammation is key when it comes to aging. There’s a term out there called “inflammaging,” which reflects that close association. Diet can make a massive difference. Focusing on a whole-food diet with plenty of fresh produce can reduce internal aging. 

Fresh foods are high in vitamins and antioxidants that fight free radicals. They also supply polyphenols, minerals, and other nutrients necessary for healthy cells.

Avoiding sugar is also key. Sugar contributes to inflammation, oxidative stress, and the internal aging process. Internal aging leads to structural changes in the skin, leading to fine lines, sagging, wrinkles, and dryness.

Sleep is also a vital part of slowing down skin aging. According to a 2017 study, just two days of sleep restriction makes a person look older and less healthy. Regularly getting a full night’s sleep (at least 8 hours) can make you appear healthier and more youthful.

So what else can we do to help our skin be its healthiest?

What Sets OneSkin Apart in Reducing External Aging? 

Most skincare products out there have toxic ingredients that can age us from the outside! Ingredients like parabens, toxic metals, and phthalates can break down the skin barrier. They can also create free radicals and oxidative damage. Even retinol can be irritating and drying to the skin, doing more harm than good. It also doesn’t remove senescent cells. 

Many of the so-called “anti-aging” cosmetics out there could be accelerating aging. Irritating ingredients and toxins can increase the accumulation of senescent cells.

I love that OneSkin has cutting-edge research into skin biology, genetics, and aging. The results speak for themselves. First, they have plenty of clinical studies to prove their products work. Second, co-founder Alessandra Zonari has a biological age 15 years younger than her current age! 

What sets OneSkin apart is its discovery of a new peptide called OS-01. Peptides are fragments of proteins, the structural components of the human body, including skin. The scientists at OneSkin studied over 900 different peptides before discovering a unique one they called OS-01. 

The Science Behind OneSkin Products

The OS-01 peptide really changes dermatology and anti-aging science. That’s because it’s the only peptide scientifically proven to reverse the skin’s biological age. This means your skin could age at a slower rate than the years pass. Your skin could be younger than you are!

OS-01 peptide reduces the accumulation of senescent cells, helping the skin tissue look and behave years younger. It also supports collagen and hyaluronic acid synthesis, which are considered biomarkers of healthy skin.

To offset the daily exposure to damaging oxidative stress, OS-01 peptide also supports repair pathways at the cellular level. As a result, the skin more effectively heals from sun damage and maintains its elasticity. That means you can still get vitamin D from the sun but not worry as much about damage.

OneSkin’s Other Active Ingredients

Besides the OS-01, OneSkin has six other active ingredients in their Face formulation. These elements were selected to complement the peptide’s ability to rejuvenate skin:

  • Pracaxi oil – Praxaci oil comes from the seeds of the Pracaxi tree and helps the skin in several ways. It’s moisturizing, smoothing, and has anti-inflammatory and antioxidant effects. It may reduce the appearance of scars by supporting collagen production.
  • Andiroba oil – Andiroba oil is an oil from the seeds of the andiroba tree. It’s rich in antioxidants to help protect the skin from free radical damage. This can help prevent fine lines, wrinkles, and age spots. It also has compounds known to stimulate cell regeneration and tissue repair.
  • Niacinamide – Aka vitamin B3, niacinamide is an important nutrient for the skin. Niacinamide helps strengthen the skin barrier, preventing moisture loss. It also stimulates collagen production and helps even out skin tone.
  • Oleic Pau Mulato Extract – This extract comes from the seeds of the Pau Mulato tree, also known as Brazilian mahogany. Oleic Paul Mulato extract also supports the skin barrier, reducing dehydration. Plus it has antioxidant and anti-inflammatory effects and stimulates tissue repair.
  • Allantoin – Allantoin naturally occurs in several plants, including comfrey and chamomile. It’s known to soothe, moisturize, and condition the skin. It also promotes tissue regeneration by stimulating collagen synthesis.
  • Hyaluronic Acid – Hyaluronic acid (HA) is a molecule found in human skin, connective tissues, and eyes. It’s important for maintaining hydration, lubrication, and elasticity in tissues. HA is used in skincare products for its hydrating and plumping effects.

OneSkin Products

OneSkin includes OS-01 in all its products, including those in its Face and Body lines. The Face line includes an entire skincare routine, including a facial cleanser, daily moisturizer, and eye cream. They’ve even created a sunscreen to further protect the skin from UV rays.

OS-01 Face 

  • The PREP Facial Cleanser – This cleanser has enzymes that help break down impurities and product residues without damaging the skin. It protects the skin’s natural barrier so it’s best prepared for the OneSkin topical supplements. Studies have shown using PREP can increase peptide absorption by 200%.
  • OneSkin OS-01 FACE Topical Supplement – OneSkin’s Face product is a topical supplement that targets the root cause of skin aging. It includes those six ingredients above, plus antioxidant ingredients like grape seed oil, rose hips, and plum seed oil.
  • OS-01 EYE Topical Supplement – The eye cream adds specific nutrients to nourish the delicate skin around the eyes. Moringa, algae, and vegan collagen help reduce dark circles and boost collagen production.
  • OS-01 SHIELD Protect + Repair – The “shield” refers to this product’s ability to help shield the skin against UV rays, reducing damage from sun exposure. This sunscreen adds vitamin C, green tea, acai extract, and tara fruit extract to further support the skin. While I don’t recommend sunscreen every day, this is a good option for those times when it’s needed!

OS-01 Body

OneSkin also has an OS-01 Body lotion to help reduce senescence throughout the body.  And clinical research shows their Topical Supplement improves skin hydration while supporting the skin barrier. Seventy percent of study participants noticed improved skin texture.

My Experience with OneSkin

I started using OneSkin products after researching their ingredients and scientific development processes. It was important to me that they were truly clean and appropriate for all skin types before recommending them on Wellness Mama.

I got to try an early release of their eye product and I absolutely loved it! Their Body lotion is great as well. I tried it for the first time after a freezing cold, windy, and long day outside in the sun. My skin just drank up the lotion and instantly felt so much better. 

I use their Face lotion for a good part of the year and my skin instantly feels lighter, tighter, and nourished. The bottle lasts me over a month and is one product that I always have in my bag when I travel.

You can learn more by tuning in to my interview with OneSkin co-founder Alessandra Zonari here. And check out OneSkin products for yourself here!

Have you tried OneSkin yet? How did it work for you? Share with us below!

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  8. Sundelin T., Lekander, M., Sorjonen, K., and Axelsson, J. (2017). Negative effects of restricted sleep on facial appearance and social appeal. Royal Society of Open Science, 4, 160918160918.
  9. Harvard Health. (2022). Do retinoids really reduce wrinkles? Harvard Health Publishing.
  10. Zonari, A., Brace, L. E., Al-Katib, K., et al. (2023). Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj aging, 9(1), 10.
  11. Banov D, Banov F, Bassani AS. Case series: the effectiveness of Fatty acids from pracaxi oil in a topical silicone base for scar and wound therapy. Dermatol Ther (Heidelb). 2014;4(2):259-269.
  12. Morikawa, T.,  et al. (2018). Collagen Synthesis-Promoting Effects of Andiroba Oil and its Limonoid Constituents in Normal Human Dermal Fibroblasts. Journal of oleo science, 67(10), 1271–1277.
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  14. Peixoto, H.,  et al. (2018). Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans. Molecules (Basel, Switzerland), 23(3), 534.
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Katie Wells Avatar

About Katie Wells

Katie Wells, CTNC, MCHC, Founder of Wellness Mama and Co-founder of Wellnesse, has a background in research, journalism, and nutrition. As a mom of six, she turned to research and took health into her own hands to find answers to her health problems. is the culmination of her thousands of hours of research and all posts are medically reviewed and verified by the Wellness Mama research team. Katie is also the author of the bestselling books The Wellness Mama Cookbook and The Wellness Mama 5-Step Lifestyle Detox.


4 responses to “My Review of OneSkin Skincare Products”

  1. Foye Stender Avatar
    Foye Stender

    Soooooo…………this says nothing about nothing. Is it good, what are your thoughts? We look to you for info.

    1. Lacy Avatar

      Agree. Need more deets about what these products did for your skin over time…?

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