How Artificial Sweeteners Affect the Body

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Artificial Sweeteners and How They Affect the Body
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It’s pretty clear that sugar isn’t healthy, especially in excess, but are artificial sweeteners the answer? Probably not. Though I do use some natural no-calorie sweeteners occasionally, I steer clear of artificial sweeteners all together.

What Are Artificial Sweeteners?

Artificial sweeteners are synthetic sweeteners that may be chemically derived but may also be derived from ”natural” sources. For example, sucralose is derived from sugar. Either way, they are highly processed.

The FDA has approved six artificial sweeteners: saccharin, aspartame, acesulfame potassium (Ace-K), sucralose, neotame, and advantame. These sweeteners are as much as 20,000 times sweeter than sugar but contain few or no calories.

Artificial sweeteners can be found in many processed and packaged foods, especially ones that boast “no added sugar.” That doesn’t mean they are good and it certainly doesn’t mean I’d consume them.

How Artificial Sweeteners Affect the Body

There’s a lot of controversy surrounding artificial sweeteners and the research can be confusing and conflicting. Here’s what we know about how these sweeteners affect the body.

Appetite and Weight Gain

Humans (and other animals) have a natural ability to regulate calories and weight based on taste and texture of food. For example, as babies we learn that the sweet taste and thick viscosity of breastmilk means calories are coming.

Studies found that ingesting artificial sweeteners can interfere with this signal loop and cause overeating. One study found that (in rats) eating foods or drinks that are sweet but contain no calories “tricks” the brain into thinking that they should keep eating.

Another study found that rats fed a saccharin-sweetened yogurt ate more calories and gained more weight than rats fed a glucose-sweetened yogurt.

However, these studies are rat studies and may not cause the same effect in humans. In fact, human studies show no direct correlation (or reverse correlation) between artificial sweeteners and weight gain or increased appetite. A 2012 review determined that more research is needed to determine the effect of artificial sweeteners on insulin, blood sugar, metabolism, and weight.

Brain Function

However, other studies found links between artificial sweetener use and brain changes. In one study, people who regularly used artificial sweeteners had a higher reward response to both saccharin and sugar than people who don’t use artificial sweeteners.

Another study found that artificial sweetener consumption influences the amygdala’s response to sugar consumption. (The amygdala is a part of the brain involved in deciphering caloric value from taste.) The study concluded that artificial sweeteners may be associated with brain changes that can affect eating behavior.

Bottom Line: Though there’s no conclusive evidence that artificial sweeteners cause increased appetite or weight gain, there is some evidence suggesting there may be a correlation.

Insulin and Blood Sugar

It’s possible that blood sugar is affected by artificial sweeteners. When we eat something with sugar in it, our body is signaled to produce insulin (which sweeps the sugar away to be metabolized or stored as fat). If we eat something with artificial sweeteners the body releases insulin but then doesn’t have any sugar to sweep away. This can cause low blood sugar.

In turn, low blood sugar causes sugar and simple carb cravings, which takes us on the blood sugar roller coaster.

A series of studies showed that mice given artificial sweeteners (compared to mice given only water or water and sugar) had blood sugar spikes in line with glucose intolerance.

A human study found that sucralose consumption increased insulin response in people with obesity. However, a review found that non-nutritive sweeteners had no adverse effects. According to PaleoLeap the researchers of this review had conflicts of interest (one worked for the International Sweeteners Association, the other works for the company that makes Splenda) so the findings should be taken with that in mind.

Bottom line: It’s unclear whether artificial sweeteners affect blood sugar and insulin. However, many people who use them do so to manage obesity and diabetes, so it would make sense to be cautious of ingesting something that could potentially make the condition worse (or at least not help).

Gut Health

We know that gut health is incredibly important so I’m cautious of anything that can disrupt it.

In the above research where mice had blood sugar spikes when using artificial sweeteners, researchers wanted to know if the glucose intolerance had something to do with gut bacteria. So researchers gave the mice antibiotics to wipe out their gut bacteria and the mice no longer had glucose intolerance.

Interestingly, when the researchers transferred the gut bacteria of mice who had ingested an artificial sweetener (saccharin) into mice whose guts were sterile, it caused these previously healthy mice to become glucose intolerant. The team analyzed the gut bacteria and found that artificial sweeteners increased the amount of a specific bacteria that has already been linked to obesity in humans.

So what to do when you want some sweetness without any of the downsides of real sugar or synthetic chemicals that (supposedly) taste like sugar?

Natural Zero-Calorie Sweeteners

Artificial sweeteners may not be the best choice, but what about natural ones?

Natural zero-calorie sweeteners (like stevia, erythritol, and xylitol) are not artificial but may still have some drawbacks. For example, stevia powder (versus the herbal extract) is highly processed and unstudied for safety. However, I do choose to use liquid stevia as an occasional treat.

Artificial Sweeteners: My Takeaway

Even if artificial sweeteners don’t directly cause disease, it makes sense that they may condition people to crave sweet foods over nutritious foods. For example, stimulation of sugar receptors (from eating sweet foods) can make people less sensitive to sweetness. That means less intensely sweet things don’t taste good (fruit doesn’t taste good and vegetables taste plain bad).

These people may not gain weight, but they likely are losing health if they are avoiding nutritious foods and instead eating low-calorie sweet foods. Weight can be a sign of health but it isn’t the only one. A person can be thin but still be unhealthy.

Also, the suggestion that a sugar substitute is healthier than sugar (if it is) doesn’t give me a lot of confidence considering how many health issues sugar can cause. My takeaway is that we have to learn to enjoy foods without added sweetness. We make the occasional treat using nutrient-dense foods and small amounts of natural sweeteners like honey or maple syrup, but keep it at a minimum.

This article was medically reviewed by Dr. Scott Soerries, MD, Family Physician and Medical Director of SteadyMD. As always, this is not personal medical advice and we recommend that you talk with your doctor.

Do you use artificial sweeteners? What’s your experience?

  1. Artificial Sweetener May Disrupt Body’s Ability To Count Calories, According To New Study. (2004, June 30).
  2. Artificial Sweeteners Linked To Weight Gain. (2008, February 11).
  3. Bellisle, F., & Drewnowski, A. (2007, February 07). Intense sweeteners, energy intake and the control of body weight.
  4. Green, E., & Murphy, C. (2012, November 05). Altered processing of sweet taste in the brain of diet soda drinkers.
  5. Rudenga, K. J., & Small, D. M. (2012, April). Amygdala response to sucrose consumption is inversely related to artificial sweetener use.
  6. Kresser, C., K., Huffman, D., M., S., Hamilton-Gibbs, R., Snoopy Storey. (2017, March 22). The Unbiased Truth About Artificial Sweeteners.
  7. Non-nutritive Sweeteners Can Increase Insulin Resistance In Those Who Are Obese. (2016, December 03).
  8. Renwick, A. G., & Molinary, S. V. (2010, July 12). Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release | British Journal of Nutrition.
  9. Brown, R. J., & Rother, K. I. (2012, August).
  10. Strawbridge, H. (2018, January 08). Artificial sweeteners: Sugar-free, but at what cost?
Katie Wells Avatar

About Katie Wells

Katie Wells, CTNC, MCHC, Founder of Wellness Mama and Co-founder of Wellnesse, has a background in research, journalism, and nutrition. As a mom of six, she turned to research and took health into her own hands to find answers to her health problems. is the culmination of her thousands of hours of research and all posts are medically reviewed and verified by the Wellness Mama research team. Katie is also the author of the bestselling books The Wellness Mama Cookbook and The Wellness Mama 5-Step Lifestyle Detox.


8 responses to “How Artificial Sweeteners Affect the Body”

  1. Ilene Avatar

    I’m a bit disappointed with your publishing this article. I feel that it’s dangerous and people will read so much and stop reading. If they use artificial sweeteners regularly they will stop before “my take” at the end of the article.
    Personally I don’t believe that someone who calls herself “The Wellness Mama” should even address such a topic. Artificial sweeteners are bad, all around. They do not need a forum as strong as yours to give them any more airtime than they deserve.

    1. Katie Wells Avatar

      I was asked about this topic a lot so I wrote about it, but I definitely didn’t recommend artificial sweeteners in any way in the article and tried to provide an accurate review of the research, as well as my opinion that I would never consume them.

  2. Ash Avatar

    Hello! Just wondering why liquid stevia is better than the unstudied powdered version? Is liquid stevia safe? Also, the link you’ve inserted for liquid stevia goes to another product… 🙂 Thanks!

  3. Karen Avatar

    Thank you for the info on sweeteners. I grew up in a home where my mother baked a cake, a pie (or 2) and a batch of cookies, every week. We had dessert after lunch and dinner every day. None of us we’re overweight. Neither of my parents had good teeth, but my mom lived to 98 and my dad to 99 and were never diagnosed w/ diabetes! I inherited their cavity prone teeth, but was diagnosed with high blood sugar in my 60’s. Everyone in my family experienced my mom’s’ sugary desserts as an expression of love. So the idea of completely eliminating them from my diet was depressing. I went through SEVERE carb withdrawal when I was first diagnosed. Extensive research led me to xylitol. It has been so helpful in adjusting to life with little to no sugar! My teeth have decreased in the number of cavities by about 80%. I can still make fruit crisps & cookies. My gut is good as long as I take probiotics. Xylitol has been a life saver for me!

  4. D. Smith Avatar
    D. Smith

    My DH has diabetes and we use erythritol once in a while and it doesn’t seem to affect him at all. He is doing a great job of controlling blood sugar numbers (which he takes every morning and evening – the other night his blood sugar was 65!) with berberine and B12 and ALA and French Maritime Pine Bark (aka pycnogenol).

    In the summer he likes strawberries sprinkled with erythritol on top of the occasional piece of my homemade pound cake. Sometimes he adds some homemade whipped cream (in which I use real sugar because I just do) and truthfully, that also hasn’t bothered him.

    I think people stress too much about food and that causes some of our most major problems.

  5. Curie Ganio Avatar
    Curie Ganio

    I used to be a frequent user of artificial and natural no calorie sweeteners and couldn’t figure out why my cravings were out of control. I too, now only have them as an occasional treat and when I make sure to prepare my self for the fact that it might cause some cravings to occur soon after. I have also found that using nutritive sweeteners such as Grade B Maple Syrup or Honey, while it does create an insulin response I don’t seem to suffer from the cravings like I do with refined sugar or the no calorie options. Of course, I use these only on occasion for a special treat, but it has made a huge difference for me.

  6. Karen Avatar

    I have switched to Cassave syrup because it has no GI (glycemic index) and it still has the viscosity of honey or maple syrup which I miss in sugar substitutes.

  7. Laura Avatar

    Katie. I’m wondering about effects unrelated to weight. I’ve heard a lot of people say that artificial sweeteners do everything from cause cancer to Alzheimer’s but I’ve never been able to find legitimate studies about this. Did you come across any research about these other concerns?

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