Natural Ways to Fight Drug-Resistant Head Lice

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Natural Ways to Fight Drug Resistant Head Lice
Wellness Mama » Blog » Natural Remedies » Natural Ways to Fight Drug-Resistant Head Lice

We all know head lice is no fun, and quite possibly a terrifying prospect for any parent to deal with. As more drug-resistant strains emerge, it takes a bit of research to know what natural methods to deal with lice actually work.

Especially when preparing for the start of school, a refresher can help! Here are some effective natural or less-harsh methods that actually work, based on research from medical journals and experience from the parenting trenches. I also include some proactive steps to hopefully avoid getting lice in the first place.

Drug-Resistant Head Lice?

Just as certain strains of bacteria have mutated to be able to survive treatment with common antibiotics, these head lice have developed mutations that allow them to survive the common treatments. Not only do insecticidal treatments douse our children in potentially dangerous endocrine disruptors and brain-affecting chemicals, but many also aren’t even effective anymore!

A 2014 study found that over 99% of lice that were tested had a mutation that let them survive treatments with insecticides permethrin and pyrethrin, the most common treatments used.

It’s almost saturated with (these genes), which means that people using permethrin and pyrethrin based products will probably have a very hard time controlling the lice,” said Kyong Sup Yoon, associate professor of biological sciences and environmental sciences at Southern Illinois University, who led the research for the current study and the 2014 study. (source)

Newer treatments use stronger strains of insecticides that lice are not yet resistant to, but can cost over $100 and often need a prescription.

It’s also good to be aware that these insecticides may contain neurotoxins and endocrine disruptors that may have a long-lasting negative effect on children, especially when used more than once over time.

What Should a Parent Do?

As a parent, the mere idea of head lice sends chills down my spine. With six kids, lice could spread very quickly at our house and be very difficult to get rid of.

We actually faced this problem a couple of years ago, and after some research, I wasn’t comfortable using the conventional treatments with insecticides, especially since our children are still so little.

I tried several of the natural remedies and suffocation methods recommended online, but none seemed to truly stop the problem, especially for one daughter who had hair too thick to comb through completely and which was perfect for hiding lice.

Within a week, we had completely eradicated the lice from our children and also discovered a lot of natural remedies for head lice that didn’t work (and a few that worked brilliantly.)

The beauty of these treatments is that they act on the lice in a physical way through dehydration or other methods and don’t rely on the insecticides that many lice are resistant to anyway.

I’ve also included a list of the things we’ve used to avoid any more outbreaks since our initial one, even in times when I know that my children were exposed to children with lice.

Natural Ways to Fight Drug-Resistant Head Lice

The study found that drug-resistant lice were resistant to insecticides. I wasn’t comfortable with using insecticides anyway, so the methods I found and tested on our children didn’t rely on them in the first place. I read the full text of the study and confirmed that these natural remedies (which worked through dehydration and physical means) would still work on mutated forms of lice.

The other advantage of these natural remedies is that I didn’t have to comb through my kids’ hair at all because the treatment doesn’t rely on removing any lice and nits.

For our boys, we shaved their heads since it was warm weather anyway, but our three girls presented a big challenge: three heads of thick, wavy hair ranging from just over shoulder length to almost waist length.

Our girls are also the most tender-headed children I’ve ever met, so nit-picking was going to be a difficult or impossible option for us, though it has been found to be effective at removing lice when used consistently. I also found in researching, that lice don’t lay eggs for at least ten days after they hatch, so as long as some form of effective natural lice remedy is used every 6-7 days for a few life cycles, nitpicking hair is not necessary.

These are the methods that worked for us, in order of effectiveness:

Saline-Based Lice Spray

The most effective remedy we used that didn’t require any chemicals or the use of a lice comb was a saline-based lice spray. The salt-based spray dehydrates and kills lice and nits on contact but isn’t harmful to a child. Though it does contain an added fragrance I would normally avoid, this option is still much, much more natural than other options and removed so much headache from the lice removal process that I was willing to use it even with the fragrance.

This spray was so simple to use too. I just sprayed on hair before bed, let stay on overnight, and shampooed their hair in the morning. It didn’t sting, it didn’t have a horrible smell like insecticide-based remedies and it (surprisingly) also left a lot of body in their hair for about a week (probably due to the salt, which I use in my own beach waves spray for volume).

This spray also comes with a lice comb, which I used as much as I could one time on each child’s hair, but even without consistent combing, our lice were gone within a week without the need for any insecticides.

The other advantage to this spray is that it can be used after exposure to other children with lice, so if I know my children have been exposed, I spray their hair at night and let them sleep with the spray in to avoid an outbreak.

Neem Shampoo

A 2012 study found that neem oil was also effective for killing lice when used externally in a shampoo. Since the saline-based lice spray needed to be washed out each morning, I used a neem-based shampoo to make sure that no lice had survived the treatment. (I used this brand and really liked it)

This shampoo is drying, so I followed up with a natural conditioner on the girls so their hair wouldn’t be too dry or tangled to brush. I found that I could also use the lice comb on their hair while it was wet and had conditioner on it, so this was the closest we came to combing their hair completely.

We continued using this shampoo until we knew that the places they had been exposed to lice had completely eliminated the problem, and I now add a few drops of neem oil to their regular shampoo to help avoid any future outbreaks.

Important note: Neem oil should never be used internally, especially on women, children, or anyone without express doctor oversight. It can have negative effects if used internally but is generally considered safe for external use. Check with a doctor before using this, or any product, if pregnant or on children.

Diatomaceous Earth

I also alternated these treatments with the use of diatomaceous earth (DE). I’ve used DE before for fleas and other pests and found some evidence that it could help kill lice as well. The tiny particles of DE have microscopic sharp sides that scrape the exoskeleton of the lice and lead to dehydration. This is another chemical-free way to help kill head lice or other pests.

Caution: DE can cause irritation if inhaled. Be careful to apply in a way that doesn’t create dust your child could inhale. I did this by having them cover their face with a face mask and a towel (and doing this myself as well), and then carefully sprinkling DE all over their scalps. We then applied a shower cap and let them watch a movie while the DE did its work before washing out.

I also used DE in treating our house to avoid future outbreaks (see below for the steps I took).

Other Important Steps to Fight a Head Lice Infestation

Since head lice can survive for a short time on bedding, clothes, or carpet, it is also important to treat the home for lice as well. These are the steps we took that prevented another infestation:

  1. I started by spraying and saturating all of the children’s hair with the saline lice spray and letting it dry. This was in the afternoon, so we left the spray on overnight while they slept.
  2. Then, I tackled the house. I started by stripping all beds, pillows and removing all clothing they had worn for the past 72 hours from their rooms. I washed all of these in hot water and used the hottest cycle in the dryer. Even just 20 minutes in the hottest setting on a dryer is supposed to kill any lice living on clothing or bedding. I also ran their pillows and stuffed animals through the dryer for 20 minutes. Any stuffed animals, cloth toys, or furniture that was too big to be washed was put in a black garbage bag and put in the attic (it was hot this time of year) for 2 weeks. This might have been overkill, but I wasn’t taking chances.
  3. I sprinkled diatomaceous earth on all carpets, let sit for 15 minutes, and vacuumed everything… twice.
  4. Then, I took all hairbrushes/combs and ran through the sanitize cycle on the dishwasher. Hairbows, hair ties, and other hair accessories were put in airtight bags for several weeks.
  5. I also parked our family car in the hot sun for several hours to kill any surviving lice in the car.

Avoiding Future Head Lice Infestations

We have not had any lice infestations since that initial time, despite exposure several times. To keep from getting another outbreak, I’ve used this lice-free spray on our children any time I know that we’ve potentially been exposed. We also use the Neem shampoo once a month or so, especially this time of year, just to be safe.

But (try) to remember, it isn’t the end of the world…

If your child comes home with lice at any point, don’t panic! I know it can be embarrassing, frustrating, and exhausting to deal with head lice, but lice are not life-threatening or dangerous… just annoying!

Even with these mutated drug-resistant lice, there are natural options that work! In my opinion, they even work better than harmful conventional insecticide-based options.

While I hope we never need these remedies for lice again, it gives me peace of mind to be prepared and have a plan ahead of time.

This article was medically reviewed by Dr. Michelle Sands, ND. She is double board certified in Integrative Medicine and Naturopathic Medicine and is also a Board-Certified Holistic Nutritionist, and competitive endurance athlete. As always, this is not personal medical advice and we recommend that you talk with your doctor.

Has your family ever dealt with head lice? What did you do that worked?

Katie Wells Avatar

About Katie Wells

Katie Wells, CTNC, MCHC, Founder of Wellness Mama and Co-founder of Wellnesse, has a background in research, journalism, and nutrition. As a mom of six, she turned to research and took health into her own hands to find answers to her health problems. is the culmination of her thousands of hours of research and all posts are medically reviewed and verified by the Wellness Mama research team. Katie is also the author of the bestselling books The Wellness Mama Cookbook and The Wellness Mama 5-Step Lifestyle Detox.


91 responses to “Natural Ways to Fight Drug-Resistant Head Lice”

  1. Leah Avatar

    I got lice from my niece last year and tried 2 different chemical shampoos that left my scalp tender and did not kill the lice. The only thing that worked was covering my hair with Listerine (The orange-y original formula), and then placing a shower cap over my hair, and putting a towel on my shoulders in case any Listerine seeped out for about 40 minutes. All the lice was dead and then I had someone pick out the nits. This was the only thing that helped…

  2. Nicol Avatar

    Our schools are just head lice breeding grounds. Mainly because they don’t spot check kids anymore. They also do not have then”no nit” policy like some public schools. The fact that it is a small farm town and everyone shares a bus seat and a locker with three other kids doesn’t help either.

    Every fall about a month into the new school year we get a notice that someone in the classroom has had a case of lice. My girls have been victims more than once. My youngest is the one that they seem to like the most.

    So I have tried several different remedies myself. Never chemicals or DE they are too dangerous for me.

    Tea tree shampoo and the “Fairy Tails” shampoo and spritz are good preventatives. But they are not effective for removing.

    I have used alcohol based hand sanitizer which kills them instantly. Then comb through the hair thoroughly. The alcohol also helps break down the “glue” on the nits so they come out easier. This method works great and is cheap since you can get a bottle for under $2 and it will treat two kids with long hair. It also makes hair super shiny.

    Plain cheap conditioner mixed with baking soda is also effective. The baking soda dries them out and causes friction to help remove nits. My youngest says it stings so even though it worked great I don’t do this one anymore.

    Coconut oil worked great and made it super easy to remove the nits with a metal nit comb. I did the treat ment on a Friday night and left it in until Monday morning. I combed it every day. It wasn’t super oily but we just used an old towel over her pillow at night.

    Adding tea tree, rosemary, and lemongrass oils to any shampoo base makes great repellent shampoo.

    We are getting ready for school to start here so I will be stocking up on cootie supplies as I buy school supplies. Hope this helps someone!!

  3. Anita Avatar

    You said you put all big furniture that you couldn’t wash in the attic. Well, I don’t have an attic or a basement and I have a huge sectional. What natural remedy would I use on that and mattresses???

    Thanks! ?

    1. Brenda Avatar

      You can just simply cover all your furniture with a bed sheet for 48 hours – any lice or eggs underneath will die and then revacuum when you remove the sheet.

      1. Kalena Avatar

        Actually, simply covering things with a sheet is not effective. Lice can live up to a couple of weeks or more without a host. Sheets are also breathable which renders it ineffective.

        1. Tina Avatar

          Actually head lice needs a warm host with food or will die with in 72 hours, body lice however can lice up to 14 days with out a host. Historically things became distorted when body lice was a big problem. There were many warnings and treatments because they carry diseases that can kill. The two became interchangeable after a time, but biologically they are not.

          1. Kalena Avatar

            I beg to differ as I have experienced this personally in dealing with an infestation of head lice on my daughters; not body lice!
            If body lice can live up to 14 days without a host, then who’s to say that head lice have not evolved that way also? It is a known fact that head lice have evolved and become superbugs which have become immune to the powerful pediculicides used to treat them, so if that’s the case, and I have seen first hand live bugs on floors and other inanimate objects that are not a “warm host” for weeks after treating, then that tells me differently. There is no distortion or confusion between head lice and/or body lice. I know very well what I was dealing with.

  4. Emily Avatar

    My youngest son came home with lice the day before Christmas break year before last, so I spent all of our break fighting the nasty little things. I treated everybody’s heads (four kids, and my husband and myself), plus the house. We had great success with freezing things that couldn’t be put in the dryer (hair bows, some toys), and bagged anything that couldn’t be either frozen or dried for two weeks. We used an enzymatic lice treatment, and I shaved the boys’ heads. Every night after showers, I combed the girls’ hair out and then dried and flat-ironed their hair while they watched movies or played games on the iPad. It was a stressful process but all the work paid off and we got rid of them! Now we use a preventative shampoo that we get from Amazon and haven’t had them again. I love all of the ideas above and plan to implement them this year!

      1. Emily Avatar

        We typically use Rosemary Repel shampoo the whole time the kids are in school, and we also spray them with Rosemary Repel spray. I know you can also make your own spray with essential oils of rosemary and tea tree. We’ve also tried TheraNeem, which we can get at Amazon or Natural Grocers but I am not crazy about how it smells. We also make sure the kids have their own headphones at school and refuse hearing screenings (which is how we got them). So far so good-over two years of having four kids in a live-ridden school, and we haven’t come home with them again.

  5. marla Avatar

    My head is itching just reading this. When my daughter got lice we use the over the counter medication more than once and it didn’t work. I started looking for natural remedies and settled on mayonnaise. I slathered her head with a thick coating of mayonnaise and then put her in a shower cap for about 18 hours. She stunk to high heaven, but the lice were gone. We now blow dry her hair regularly and they haven’t returned, but I also don’t know if she’s been exposed again.

  6. Karen Avatar

    Cheapest and safest way to kill lice is with OREGANO.

    Yes, just regular oregano spice you buy at the grocery store. Get the cheap kind, that is fine. Put it in a pan, cover it with water, and boil it for at least ten minutes.

    Strain it if you wish, I don’t, but you can. Put this in your shampoo bottle, half shampoo, half boiled oregano.

    This is said to kill 100% of lice and 99% of their eggs immediately.

  7. Angelica Avatar

    When I got head lice from a mysterious source (?), it took a long time before I realised it so my head was… a nightmare. Like really.
    I solved it with 100% silicone solution (suffocates the lice) and daily comb-outs on myself. Worked like a charm.

  8. Anj Avatar

    ive never had to deal with them yet, however my sons school recommend just plain smothering them with cheap hair conditioner – leave it on for 10 minutes, them using a bit comb, comb me out. That deals with the hair, then washing all bedding etc in hot water. I guess there must be a non toxic alternative to shop bought conditioner…

  9. Lauren Avatar

    Mayonnaise and a lice comb worked wonders for us! Mayo under a shower cap for a couple hours, comb it through, rinse it out, and then use the lice comb and feel each strand for nits. Sounds like a lot of work, but you only have to do it once if you are precise.
    I do wish I had tried DE though. I love the stuff!!

  10. heidi Avatar

    We live in aisia where the chemical treatment is hard to come by, but id rather do natural anyways. In the last year 2 daughters have gotten lice 2x and one son 1x. We drowned them overnight in coconut oil, then rinse off with acv. Workes everytime. We also spray behind the ears a mix of water lavendar and tea tree oil, keeps them away.

    1. Kerri Taschuk Avatar
      Kerri Taschuk

      We found lice on our daughter after Christmas dinner and have done this process for the last 48 hours. I rinsed her hair in Apple Cider Vinegar and let it dry, and then we applied coconut oil and left it for 3 hours. We washed it and then combed through it. Anything that moved, stopped and we picked everyrhing we could see out and then we reapplied coconut oil and tea tree and she slept like that. In the morning we shampooed with a tea tree wash and conditioner and then when through her hair with tweezers. Through the day we kept tea tree oil and hairspray in it, and then at night we started the coconut oil process again, keeping it in overnight, washing and checking again. In 48 hours we are down to finding only about 7 eggs in her hair. Crossing my fingers we are down to zero. Only the morning will tell..but we will be doing this for the next week to be sure. I am also going to try a preventative spray of Rose water, lavendar and tea tree on the rest of us.Thank goodness for winter holidays! That’s just the hair, never mind the house cleaning…yikes!

    1. Kalena Avatar

      They actually can, and do survive for up to two weeks without a host!!
      I battled headlice reinfestations with my daughters for a very long time. We just could not get rid of them regardless of what we did! The prescription poison never worked on the lice and nearly killed me and then I just refused anything that was not a natural, safe remedy. I kept trying various treatments but they would keep coming back. I’m so glad that we are finally done with the lice for good.

  11. Terelyn Avatar

    I had the very unpleasant experience of getting head lice from my 2 nieces about 4 years ago. I didn’t know about DE, and after several bottles of the insecticide not working, I ended up shaving my head (yes, I tied the salt thing, tea tree oil, and Neem, too). The good thing was that it was summer time and I had some cute hats to wear out in public, but it took over a year for my hair to grow out. I hope I’ll never have to shave my head again, but it WAS nice not to have to spend so much time washing and drying it actually.

  12. Alicia Avatar

    Is there a homemade salt spray that we can make that would work the same as the salt spray? I am a teacher so I will inevitably get lice but am very allergic to fragrances. The salt spray option is the only more natural product I can buy in my area, but it has fragrance. Any chance you would know how to make one? Would your beach spray work on its own?

    1. Wellness Mama Avatar

      In theory, that should work. I haven’t had the chance (thankfully) to try it yet, but it follows the same idea, so it should. I’d think that especially adding tea tree oil or neem oil would make it more effective.

      1. Heather Avatar

        If you use tea tree or other oils with homeopathics the oils can overwhelm the homeopathic remedies. I’d try the Nat Mur or tea tree but not both.

      1. Francis Avatar

        You can put about 10 drops in your favorite shampoo or get a tea tree oil shampoo–we get the one from Trader Joe’ haven’t had lice in the five years we’ve been using it..they HATE the smell and they don’t approach. Good Luck! !

  13. Kim Avatar

    We had lice in January. I got it too! Gross. I tried the OTC stuff. I used the comb after I washed the treatment out and, to my horror, combed 2 LIVE lice out of my hair!!! So I frantically went online to find some home remedies. Here’s what I did that worked:
    I saturated my hair with olive oil that had a few drops of tea tree oil mixed in. I placed a bag securely over my head and slept that way all night. In the morning, I took a shower and washed out all the oil with shampoo and blow dried my hair. I went to the kids’ school and had the nurse check me and they were gone!!!
    I might suggest to use caution with the tea tree oil if you have sensitive skin. It is probably isn’t even necessary since the oil is probably what suffocated the lice.

  14. Heather Avatar

    Thank you, thank you, Katie! Saw these reports just as we are starting kindergarten for the first time. I’ve been freaking out wondering what to do. Going to stock up, be prepared, and forget about it! Thank you for sharing!

  15. Stefani Avatar

    Blow drying. When we had an outbreak, I read about using a cold hair-dryer on dry hair in sections to dry out the lice. Since then, I started blow-drying my daughter’s hair after its weekly wash. Haven’t had a re-infestation since.

  16. Valerie Avatar

    Thanks for sharing this! Just curious, what are your thoughts/findings/experience with tea tree oil? Yeah or neh?

    1. Lisa Avatar

      Tea tree oil is supposed to be effective, but beware of use around pets. I have hedgehogs and tea tree oil is deadly for them. Even cats and dogs cannot tolerate full strength tea tree oil. However, I understand that it is perfectly fine on humans, and does work.

  17. Jamie Avatar

    Tea tree oil and coconut oil kills lice. There is a shampoo by Nature’s Gate that works great for lice that contains Tea Tree Oil. Or you can just make your own wash with castille soap, tea tree oil and coconut oil.

    1. bettina ferrando Avatar
      bettina ferrando

      I would love your recipe for the tea tree/coconut oil/castille soap shampoo. I’m determined that my kids won’t get lice this year. It was a nightmare last year when they did so I’m going in to prevention mode.


    2. Kath Avatar

      This sounds like exactly what i need, what ratio if soap and oil do u use. Thanks and have a great day.

    3. jennifer Avatar

      I tried all of those and still my daughter seems to return with it a month or later. i have 7 children and i can get rid of it on all of them but having a really hard time getting it to stay gone on her . she does have thinker and longer hair . Im at my wits end. ive tried applecider and coconut oil. im trying tea tree now in the shampoo and also diluting and washing everything down with a mixture I made also spraying everywhere.

    4. Kim russell Avatar
      Kim russell

      I had to help my sister avoid lice on a trip to a third world country where it runs rampant. I bought a Rosemary shampoo and added tea tree, 3-4 drops of eucalyptus and 3-4 drops of nutmeg oil. She had a nice trip and the lice stayed away! Kim

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